Department of Psychiatry Faculty

Arthur A. Simen, M.D., Ph.D. Assistant Professor of Psychiatry Yale University School of Medicine 300 George Street, Suite 901 New Haven, CT 06511 Phone: (203) 785-7361 Fax: (203) 785-7357 Email: arthur.simen@yale.edu

Education

Ph.D. 1999, The University of Chicago
M.D. 2001, The University of Chicago

Laboratory Personnel

Laboratory Resources

Areas of Expertise

Human genetics
Molecular neurobiology

Achievements and Honors

Lustman Research Award, Yale University Department of Psychiatry, 2005.
Lustman Research Award, Yale University Department of Psychiatry, 2003.
NARSAD Young Investigator Award, 2005.
Yale K12 Mentored Clinical Research Scholar Award, 2005.

Research Interest

Our goal is to understand the molecular mechanisms by which genetic, epigenetic, and environmental factors contribute to risk for complex psychiatric diseases, including Major Depressive Disorder and Bipolar Disorder. We are pursuing highly integrated basic neuro-developmental studies and human genetic studies in an effort to develop novel approaches to identifying disease genes. We use a number of molecular and computational methods toward these ends, including neuronal stem cell cultures, mouse models, real-time PCR, DNA binding assays, confocal microscopy, genomic microarray analysis, linkage and association analysis, RNA interference, viral-mediated gene expression and gene knockdown, and methylation analysis.

Publications of Note

Bushell, T., Endoh, T., Simen, A. A., Ren, D., Bindokas, V. P. and Miller, R. J. (2002). Molecular components of tolerance to opiates in single hippocampal neurons. Mol Pharmacol 61, 55-64.

Oh, S. B., Endoh, T., Simen, A. A., Ren, D. and Miller, R. J. (2002). Regulation of calcium currents by chemokines and their receptors. J Neuroimmunol 123, 66-75.

Simen, A. A., Lee, C. C., Simen, B. B., Bindokas, V. P. and Miller, R. J. (2001). The C terminus of the Ca channel alpha1B subunit mediates selective inhibition by G-protein-coupled receptors. J Neurosci 21, 7587-97.

Meucci, O., Fatatis, A., Simen, A. A. and Miller, R. J. (2000). Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival. Proc Natl Acad Sci U S A 97, 8075-80.

Simen, A. A. and Miller, R. J. (2000). Involvement of regions in domain I in the opioid receptor sensitivity of alpha1B Ca(2+) channels. Mol Pharmacol 57, 1064-74.

Simen, A. A. and Miller, R. J. (1998). Structural features determining differential receptor regulation of neuronal Ca channels. J Neurosci 18, 3689-98.

Meucci, O., Fatatis, A., Simen, A. A., Bushell, T. J., Gray, P. W. and Miller, R. J. (1998). Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity. Proc Natl Acad Sci U S A 95, 14500-5.

Sanacora G, Kendell SF, Levin Y, Simen AA, Fenton LR, Coric V, Krystal JH. Preliminary Evidence of Riluzole Efficacy in Antidepressant-Treated Patients with Residual Depressive Symptoms. Biol Psychiatry 2006.

Wang M, Ramos BP, Paspalas CD, Shu Y-S, Simen AA, Duque A, Vijayraghavan S, Brennan A, Dudley A, Nou E, Mazer JA, McCormick DA, Arnsten AFT, 2A-Adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex. Cell. In press 2007.

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