Department of Psychiatry Faculty

Ronald Duman, PhD Professor of Psychiatry and Pharmacology Director, Division of Molecular Psychiatry and Abraham Ribicoff Research Facilities 34 Park Street Tel: 203-974-7726 Fax: 203-974-7724 Email: Ronald.Duman@Yale.edu

Education

Ph.D., 1985, University of Texas Medical School, Houston, TX

Research Interest

Studies in Dr. Duman's laboratory are focused on identifying the molecular and cellular adaptations that underlie the actions of psychotropic drugs and stress, including adaptations of receptors, signal transduction proteins, gene transcription factors, and neurotrophic factors. These various types of adaptations contribute both to the damaging effects of stress as well as to the therapeutic actions of psychotropic drug treatment (i.e., antidepressants).

Area of Expertise

Depression, antidepressants, stress,
Molecular biology, neuropharmacology
Signal transduction pathways, gene expression

Laboratory Personnel

Heath Schmidt and Vanja Duric, Postdoctoral Fellows
Mounira Banasr and Bhavya Voleti, Postdoctoral Associates
Hyo Jung Kang and Eri Nishida, Postdoctoral Associates
Rose Terwilliger and Lee Schlesinger, Research Associates
Xiaoyung Li, Matt Girgenti, Research Assistants
Rebecca Kinsler and Ja Wook Koo, PhD. Students

Achievements and Honors

• Laureate Psychiatry Investigator Award, 1989
• NARSAD Young Investigator Award, 1989
• Neuropsychopharmacology, Editorial Advisory Board, 1996
• Eli Lilly Young Investigator Award in Pharmacology, 1996
• J Neurochem, Editorial Advisory Board, 1997; NARSAD Independent Investigator Award, 1997
• van Ameringen Investigator Award, 1998
• J Pharmacol Exp Ther, Associate Editor, 1998
• Mol Pharmacol, Editorial Advisory Board, 1998
• Neuropsychopharmacolgy, Associate Editor, 1998
• van Ameringen Investigator Award, 1998
• J ECT Investigator Award, 1999
• Scientific Advisory Board, Anxiety Disorders Association of America, 1999
• Anna Monika Award in Depression, 2001
• Nola Maddox Falcone Prize for Affective Disorders Research, 2002
• Paul Janssen Prize for Psychopharmacology, 2003.
• Distinguished Alumni Award, Univ. Texas, 2004
• NARSAD Distinguished Investigator Award, 2005
• NIMH MERIT Award, 2005
• CINP Basic Science Research Award, 2006

Fujioka T, A Fujioka, and RS Duman (2004) Activation of cAMP signaling facilitates the morphological maturation of new neurons in adult hippocampus. J Neurosci 24:319-328.

Dow A, DS Russell, and RS Duman (2005) Up-regulation of activin mRNA and Smad2 phosphorylation by antidepressant treatment in the rat brain: Effects in behavioral models. J Neurosci 25:4908-4916.

Simen BB, CH Duman, AA Simen, and RS Duman (2006) TNF? in depression and anxiety: behavioral consequences of individual receptor targeting. Biol Psych 59:775-785.

Newton SS, MJ Girgenti, EF Collier, and RS Duman (2006) Electroconvulsive seizure increases adult hippocampal angiogenesis in rats. Eur J Neuroscience 24:819-828.

Warner-Schmidt JL and RS Duman (2007) Vascular endothelial growth factor is an essential mediator of the neurogenic and behavioral actions of antidepressants. Proc Natl Acad Sci 104:4647-4652.

Banasr, M, GW Valentine, XY Li, S Gourley, J Taylor, and RS Duman (2007) Chronic Stress Decreases Cell Proliferation in Adult Cerebral Cortex of Rat: Reversal by Antidepressant Treatment. Biological Psychiatry 62:496-504.

Kang H-J, DH Adams, A Lin, BB Simen, G Rajkowska, C Stockmeier, J Overholser, HY Meltzer, G Jurjus, L Konick, B Simen, SS Newton, and RS Duman (2007) Gene expression profiling in postmortem prefrontal cortex of major depressive disorder. J Neurosci 27:311-320.

Hunsberger JG, SS Newton, AH Bennett, CH Duman, DS Russell, S Salton, RS Duman (2007) Novel role of exercise-regulated gene VGF in models of depression. Nature Med 13:1476-1482.

Koo JW and RS Duman (2008) IL-1R? is an essential mediator of the anti-neurogenic and anhedonic effects of stress. PNAS USA, epub.

Tanis KQ, RS Duman, and SS Newton (2008) A dynamic atlas of CREB binding and activity in brain: regional specificity and induction. Biol Psych, Epub ahead of print.

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