Reproductive Immunology

2/15/01


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Table of Contents

Reproductive Immunology

Maternal Immune response to the fetus

Why Did you mother reject you?

Why Were You Not Rejected By Your Mother

Immune-Reproduction

Maternal Immune Response

Redefining the Immunology of pregnancy

PPT Slide

Redefining the Immunology of pregnancy

Classical Definition of the Immune System

Innate Immune response

Adaptive immune response (1)

PPT Slide

Adaptive immune response (2)

PPT Slide

The Fetus as a Tissue Allograft

PPT Slide

Immunology of Pregnancy

Mechanical Barrier

Mechanical Barrier

Immune Response to Paternal Antigens

Hemolytic Disease of the New Born

Suppression of the maternal Immune System

Suppression of the Maternal Immune System

Major Histocompatibility Complex (MHC)

MHC class I

Trophoblast expression of MHC Class I

Cytokines and Pregnancy

Cytokines and Pregnancy

PPT Slide

What is the mechanism by which Th-1 or Th-2 type cytokines affect trophoblast survival and function

Local Immune suppression:

Fas/Fas Ligand Mediated Apoptosis

Fas Mediated Apoptosis

FasL expression in trophoblast Cells

Proposed Model

Author: Dr. Gil Mor

Email: gil.mor@yale.edu

Home Page: http://info.med.yale.edu/obgyn/reproimmuno/

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