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Richard Lifton, M.D.,Ph.D.
Chairman, Department of Genetics
Sterling
Professor of Genetics, Medicine (Nephrology), & Molecular
Biophysics & Biochemistry
Investigator, Howard Hughes Medical
Institute
B.A. Dartmouth College, 1975
M.D., Stanford University School of Medicine,
1982
Ph.D., Stanford University School of
Medicine, 1986
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With tools form the human genome project, we are using
molecular genetic approaches to identify the pathways that underlie
common human diseases. Once identified, we investigate the mechanisms
that link genotype and phenotype. These studies are identifying new
mechanisms underlying human diseases including hypertension, hypercholesterolemia
and osteoporosis, and are providing new opportunities for diagnostic
and therapeutic interventions. |
Wilson FH, Disse-Nicod è me S, Choate KA,
Ishikawa K, Nelson-Williams C, Desitter I, Gunel M, Milford DV, Lipkin
GW, Achard JM, Feely MP, Dussol B, Berland Y, Unwin RJ, Mayan H, Simon
DB, Farfel Z, Jeunemaitre X, Lifton RP. Human Hypertension
Caused by Mutations in WNK Kinases. Science, 293:1107-1112, 2001.
Boyden LM, Mao J, Belsky J, Mitzner L, Farhi A, Mitnick MA, Wu D,
Insogna K, Lifton RP. High bone density due to a mutation in
LDL-receptor-related protein 5. New Engl J Med. 346:1513-1521, 2002.
Wilson FH, Hariri A, Farhi A, Zhao H, Peterson K,
Toka HR, Nelson-Williams C, Raja KM, Kashgarian M, Shulman GI, Scheinman
SJ, Lifton RP. A cluster of metabolic defects caused by mutation
in a mitochondrial tRNA. Science, 306: 1190-1194; published online in
Science Express, 21 October 2004. |
