Organization of the Program

The structure of the Center is predicated on the evolving critical need of investigators to combine novel technologies designed to understand the functional relationships between chromatin structure and mRNA and protein expression, by facilitating experimentation on highly purified and well-characterized stem cell subpopulations (both murine and human), and to do so with newly created informatics technology that can clarify and classify the meaning of changes in hundreds or even thousands of parameters resulting from a single experiment.

The Center has three cores, plus an administrative unit:

• Stem Cell Preparation & Analysis
• Gene Expression & Genomic Analysis
• Bioinformatics & Biostatistics
• Administration

The cores are designed to be:

• highly interactive, taking advantage of new methodologies including chromatin immunoprecipitation and study of gene expression using novel genomic DNA microarrays
• not limited to providing technology
• structured to provide ongoing intensive training to the participating investigators
• active in enhancing and expanding research in molecular hematology by providing a pilot project program and by supporting regional seminars with the goal of rapid dissemination of critical knowledge to and from the wider hematologic community

Administration

• Organization Chart