Mark R. Cullen , MD Professor of Medicine and Public Health Director, Occupational and Environmental Medicine 135 College Street Room 373 Phone: 203-785-6434 Fax: 203-785-7391 Clinical appointments: 203-785-4197 e-mail: mark.cullen@yale.edu

M.D., Yale University, 1976
A.B., Harvard University, 1971
Residency, Yale University

Research Activities

Isocyanate asthma, chronic beryllium disease, asbestos and cancer, work organization and occupational injury and diseases.

Clinical Activities

Occupational and environmental diseases.

Selected Publications

1. Cullen MR, Barnett MJ, Balmes JR, Cartmel B, Redlich CA, Brodkin CA, Barnhart S, Rosenstock L, Goodman GE, Hammar SP, Thornquist MD, Omenn GS. 2005. Predictors of lung cancer among asbestos-exposed men in the {beta}-carotene and retinol efficacy trial. Am J Epidemiol 161(3):260-70.

2. Cullen MR. 2005. Screening for chronic beryllium disease. One hurdle down, two to go. Am Rev Resp Crit Care Med 171:3-4.

3. Sood A, Beckett WS, Cullen MR. 2004. Variable response to long-term corticosteroid therapy in clinically apparent chronic beryllium disease. Chest 126:2000-7.

4. Woskie SR, Sparer J, Gore R, Stowe M, Bello D, Liu Y, Youngs F, Redlich C, Cullen MR. 2004. Determinants of isocyanate exposures in autobody repair and refinishing shops. Annals of Occupational Hygiene 48:393-403.

5. Redlich CA, Stowe MH, Coren BA, Wisnewski AV, Holm CT, Cullen MR. 2002. Diisocyanate-exposed auto body shop workers: A one-year follow-up. Am J Ind Med 42:511-18.

6. Redlich CA, Stowe MH, Wisnewski AV, Eisen EA, Karol MH, Lemus R, Holm CT, Chung JS, Sparer J, Liu Y, Woskie SR, Appiah-Pippim J, Gore R, Cullen MR. 2001. Subclinical immunologic and physiologic responses in hexamethylene diisocyanate-exposed auto body shop workers. Am J Ind Med 39:587-97.

7. Vork KL, Hammond SK, Sparer J, Cullen MR. 2001. Prevention of lead poisoning in construction workers: A new public health approach. Am J Ind Med 39:243-253.

8. Cullen MR. 1999. Occupational health in the 20th century: Spiraling to the future. Ann Rev Pub Health 20:1-13. 

9. Redlich CA, Karol MH, Graham C, Homer RJ, Holm CT, Wirth JA, Cullen MR. 1997. Demonstration of airway isocyanate-adducts in human HDI-induced asthma. Scand J Work Envir Health 23:227-31.

10. Cullen MR. 1996. The amphibole hypothesis: gone, but not forgotten. Am J Pub Health 86:158-9.

11. Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cherniack MG, Cullen MR, et al. 1996. Effects of the combination of beta-carotene and vitamin A on lung cancer incidence, total mortality and cardiovascular mortality in smokers and asbestos workers. New Eng J Med 334:1150-55. 

12. Merrill WW, Carter D, Cullen MR. 1991. The relationship between large airway inflammation and airway metaplasia. Chest 100: 131-5

13. Cullen MR, Lopez-Carrillo L, Alli B, Pace PE, Shalat SL, Baloyi RS. 1991. Chrysotile asbestos and health in Zimbabwe. II: Health survey among active miners and millers. Am J Indust Med 19:171-82. 

14. Cullen MR, Cherniack MG, Rosenstock L. 1990. Medical Progress: Occupational Medicine. New Eng J Med 322:594-601 (part 1), 675-83 (part 2). 

15. Cullen MR, Cherniack MG. 1989. The spectrum of occupational disease in an academic hospital-based referral center in Connecticut, 1979-87. Arch Intern Med 149:1621-6. 

16. Welch LS, Cullen MR. 1988. Effects of exposure to ethylene glycol ethers on shipyard painters. III: Hematologic effects. Am J Indust Med 14:527-36. 

17. Welch LS, Schraeder SM, Turner TW, Cullen MR. 1988. Effects of exposure to ethylene glycol ethers on shipyard painters. II: Male Reproduction. Am J Indust Med 14:509-26.

18. Redlich CA, Beckett WS, Sparer J, Barwick KW, Reily CA, Miller H, Siegal S, Cullen MR. 1988. Liver disease associated with occupational exposure to the solvent dimethylformamide. Ann Intern Med. 105:680-86.

19. Cullen MR, Kominsky JR, Rossman MD, Cherniack, MG, Rankin JA, Balmes JR, et al. 1987. Chronic beryllium disease in a precious metal refinery: clinical epidemiologic and immunologic evidence for continuing risk from exposure to low level beryllium fume. Am Rev Resp Dis 135:201-8. 

20. Cullen MR, Robins JM, Eskenazi B. 1983. Adult inorganic lead intoxication - presentation of 31 new cases and a review of recent advances in the literature. Medicine (Baltimore) 62:221-47. 

21. Cullen MR, Balmes J, Robins J, Smith GW. 1981. Respiratory tract disease caused by oil mist exposure from a steel rolling tandem mill. Am J Indust Med 2:51-9.