Jonathan S. Bogan

Assistant Professor
Section of Endocrinology & Metabolism

Dr. Jonathan Bogan is an Assistant Professor of Medicine and Cell Biology at Yale University School of Medicine. His special interests are in type 2 diabetes and metabolic diseases. Dr. Bogan is Board Certified in both Internal Medicine and Endocrinology and Metabolism, and is a member of the American College of Physicians, The Endocrine Society, and the American Diabetes Association. He has been a member of the Yale Medical School faculty since 2002.

Research Interests

Dr. Bogan’s research seeks to understand how glucose uptake is regulated in fat and muscle cells. In these cell types, insulin causes GLUT4 glucose transporters to move from internal membranes to the cell surface. GLUT4 can then transport glucose into the cells, removing it from the bloodstream. This process is defective in insulin-resistant states such as type 2 diabetes.

Dr. Bogan’s laboratory identified a previously uncharacterized protein, TUG, as a major regulator of GLUT4 targeting and glucose uptake. TUG binds GLUT4 and traps it intracellularly in fat cells not exposed to insulin, causing the accumulation of GLUT4 transporters in specialized “insulin-responsive vesicles.” Insulin stimulates the release of GLUT4 from TUG, thus mobilizing GLUT4 to the cell surface to enhance glucose uptake. Current work is directed to understand how and where TUG retains GLUT4 within unstimulated cells, and how insulin acts on a GLUT4-TUG protein complex to liberate GLUT4. A second area of research studies the control of glucose uptake in muscle, and examines importance of these pathways for overall glucose homeostasis. Finally, studies are now underway to determine how dysregulated GLUT4 targeting may contribute to insulin resistance.

A list of Dr. Bogan’s publications is available via COS.

Dr. Bogan’s Cell Biology webpage is here.

Education:	B.S., (Electrical Engineering) Yale University, 1986 M.D., (Genetics) Harvard Medical School and Harvard-M.I.T. Division of Health Sciences and Technology, 1992
Training:	Residency: Massachusetts General Hospital, Medicine, 1992-94 Fellowship: Massachusetts General Hospital, Endocrinology & Metabolism, 1994-98 Visiting Scientist: Whitehead Institute for Biomedical Research, 1995-2002

Contact

Campus Address
Department of Internal Medicine
Section of Endocrinology
Yale University
School of Medicine
PO Box 208020
New Haven, CT
06520-8020

E-mail
jonathan.bogan@yale.edu

Office Phone
203.785.6319

Fax
203.785.6462